Tim Clark is Director of Informatics at the MassGeneral Institute for Neurodegenerative Disease (MIND); Director of the Massachusetts General Hospital Biomedical Informatics Core; and an Instructor in Neurology at Harvard Medical School. His research group explores innovative applications in neuroinformatics, scientific social media, and biomedical Semantic Web, as well as classical computational biology. Tim serves on the Executive Committee of the Massachusetts Alzheimer Disease Research Center (http://www.madrc.org), where he collaborates closely with bench and clinical researchers to help find a cure for Alzheimers and other neurodegenerative disorders. He has been a principal investigator for several influential biomedical web communities, tools, and ontologies, including: Pain Research Forum (http://painresearchforum.org), MS Discovery Forum (http://msdicoveryforum.org), and StemBook (http://stembook.org); the SWAN (http://purl.org/swan/) and AO (http://purl.org/ao/) ontologies for biomedical communication; and the DOMEO web annotation framework (http://annotationframework.org). Tim was formerly Vice President of Informatics at Millennium Pharmaceuticals (now a unit of Takeda Pharmaceuticals) where his group developed one of the first integrated platforms in bio- and chemi-informatics in the pharmaceutical industry. He began his career in life sciences informatics at the National Center for Biotechnology Information, NIH, where he collaborated on development of GenBank, the Entrez platform, and the PubMed prototype. Tim is a member of the Editorial Board of the journal Briefings in Bioinformatics; the Advisory Committee of the World Wide Web Consortium (http://w3.org); and the Scientific Advisory Boards of the NIH Neuroscience Information Framework (http://www.neuinfo.org/), and OpenPHACTS, a €16m EU drug development informatics initiative in collaboration with the European Pharmaceutical Manufacturers Association. He also co-founded and was first program director of the Harvard Initiative in Innovative Computing (with Prof. of Astronomy Alyssa Goodman) and chaired the World Wide Web Consortium’s HCLS-IG Scientific Discourse Task from 2007-2012.