Jeffrey Grethe

FORCE11 Member since August 21, 2013
  • Organization/Institution: University of California, San Diego


I am currently a co-Principal Investigator for the Neuroscience Information Framework (NIF; and PI for the NIDDK Interconnectivity Network (DKnet; in the Center for Research in Biological Systems (CRBS; at the University of California, San Diego. NIF is an open source information framework enabling neuroscientists around the world to access a rich virtual environment identifying and providing access to neuroscience-relevant data and resources, to advance scientific inquiry leading to new discoveries and treatments of human neurological disorders. Unlike more general search engines, NIF provides deeper access to a more focused set of resources that are relevant to neuroscience, provides search strategies tailored to neuroscience, and also provides access to content that is traditionally “hidden” from web search engines (i.e. the hidden or deep web). Throughout my career, I have been involved in enabling collaborative research, data sharing and discovery through the application of advanced informatics approaches. This started at USC with my involvement in the Human Brain Project and continues today with my work on NIF and affiliated projects (MONARCH, DKnet) and the International Neuroinformatics Coordinating Facility (where I am on the Oversight Committee for their Standards and Data Sharing Program).  When I transitioned to the University of California, San Diego, I was Executive Director of BIRN Coordinating Center. As part of the BIRN project we deployed an international collaborative network that supported hundreds of researchers and Terabytes of data spread across more than 30 institutions. Infrastructure from our work in BIRN has been applied to other projects such as the Community Cyberinfrastructure for Advanced Microbial Ecology Research and Analysis (CAMERA; project, where I led the transition of the infrastructure to a workflow based analysis platform. Work in BIRN also led to novel research in data federation and the use of ontologies that we are now applying to current projects such as NIF.  The work in NIF has led to the underlying infrastructure being utilized by a number of affiliated projects funded by NIH and NSF (Earthcube CINERGI).  This underlying infrastructure (SciCrunch; will be available to the broader community in early 2014.